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Sftpdtm1Haw
Targeted Allele Detail
Nomenclature
Symbol: Sftpdtm1Haw
Name: surfactant associated protein D; targeted mutation 1, Samuel Hawgood
MGI ID: MGI:1931531
Synonyms: Sftpd-, Spd-, SP-D-
Gene: Sftpd  Location: Chr14:41172214-41185149 bp, - strand  Genetic Position: Chr14, 22.36 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:50147
Parent Cell Line:  CB1-4 (ES Cell)
Strain of Origin:  C57BL/6J x (Rb(11.16)2H x Rb(16.17)32Lub)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Replacement of exon 2 with a neomycin cassette. (J:50147)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sftpd Mutation:  4 strains or lines available
References
Original:  J:50147 Botas C, et al., Altered surfactant homeostasis and alveolar type II cell morphology in mice lacking surfactant protein D. Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11869-74
All:  34 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory