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Vtntm1Dgi
Targeted Allele Detail
Nomenclature
Symbol: Vtntm1Dgi
Name: vitronectin; targeted mutation 1, David Ginsburg
MGI ID: MGI:1931522
Synonyms: VN-
Gene: Vtn  Location: Chr11:78499120-78502325 bp, + strand  Genetic Position: Chr11, 46.74 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:30296
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neomycin cassette replaced all eight exons. Western blot analysis did not detect protein in plasma of homozygous mutant mice, and cell adhesion experiments with sera derived from homozygous mice demonstrated that serum spreading activity was absent. (J:30296)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Vtn Mutation:  3 strains or lines available
References
Original:  J:30296 Zheng X, et al., Vitronectin is not essential for normal mammalian development and fertility. Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12426-30
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/04/2020
MGI 6.14
The Jackson Laboratory