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Targeted Allele Detail
Symbol: Nr5a1tm1Jmi
Name: nuclear receptor subfamily 5, group A, member 1; targeted mutation 1, Jeffrey Milbrandt
MGI ID: MGI:1931426
Synonyms: SF1 -
Gene: Nr5a1  Location: Chr2:38692656-38714542 bp, - strand  Genetic Position: Chr2, 24.42 cM
Germline Transmission:  Earliest citation of germline transmission: J:35577
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsReplacement of ~100 bp of genomic sequence with a neomycin cassette. This region corresponded to the coding sequences for one of the zinc finger domains. (J:35577)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nr5a1 Mutation:  19 strains or lines available
Original:  J:35577 Sadovsky Y, et al., Mice deficient in the orphan receptor steroidogenic factor 1 lack adrenal glands and gonads but express P450 side-chain-cleavage enzyme in the placenta and have normal embryonic serum levels of corticosteroids. Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):10939-43
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.13
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