Cd19^tm1(cre)Cgn
Targeted Allele Detail

Summary

• Symbol: Cd19^tm1(cre)Cgn
• Name: CD19 antigen; targeted mutation 1, University of Cologne
• MGI ID: MGI:1931143
• Synonyms: B-Cre, CD19-, Cd19cre, Cd19^Cre, CD19-Cre, CD19-KO
• Gene: Cd19 Location: Chr7:126007622-126014061 bp, - strand Genetic Position: Chr7, 69.01 cM, cytoband F3-F4
• Alliance: Cd19^tm1(cre)Cgn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:27463
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Cd19^tm1(cre)Cgn expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Cd19 (MGI:88319)

• Mutation details: In-frame insertion of a cre recombinase gene into the first coding exon followed by an fFRT site flanked neomycin resistance gene cassette. A frameshift mutation was also introduced into exon 5. This allele expresses cre recombinase specifically in B lineage cells throughout development. (J:27463)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cd19 (mouse) Summary of all recombinase alleles driven by Cd19. Comparative matrix view of recombinase activities Alliance mouse Cd19 gene page

Disease models

Expression

In Mice Carrying this Mutation:	8 assay results 5 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Cd19^tm1(cre)Cgn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 11 strains available Cell Lines: 0 lines available
• Carrying any Cd19 Mutation: 56 strains or lines available

References

• Original: J:27463 Rickert RC, et al., Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. Nature. 1995 Jul 27;376(6538):352-5
• All: 705 reference(s)