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Cd19tm1(cre)Cgn
Targeted Allele Detail
Nomenclature
Symbol: Cd19tm1(cre)Cgn
Name: CD19 antigen; targeted mutation 1, University of Cologne
MGI ID: MGI:1931143
Synonyms: B-Cre, CD19-, Cd19cre, Cd19Cre, CD19-Cre, CD19-KO
Gene: Cd19  Location: Chr7:126408450-126414870 bp, - strand  Genetic Position: Chr7, 69.01 cM, cytoband F3-F4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:27463
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mutation detailsIn frame insertion of a cre recombinase gene into the first coding exon followed by an frt-flanked neomycin cassette. A frameshift mutation was also introduced into exon 5. This allele expresses cre recombinase specifically in B lineage cells throughout development. (J:27463)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Cd19     Summary of all recombinase alleles driven by Cd19.
 

Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 6 strains available      Cell Lines: 0 lines available
Carrying any Cd19 Mutation:  9 strains or lines available
References
Original:  J:27463 Rickert RC, et al., Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. Nature. 1995 Jul 27;376(6538):352-5
All:  304 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory