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Hesx1tm1Icar
Targeted Allele Detail
Nomenclature
Symbol: Hesx1tm1Icar
Name: homeobox gene expressed in ES cells; targeted mutation 1, Iain C A F Robinson
MGI ID: MGI:1931124
Synonyms: Hesx1-
Gene: Hesx1  Location: Chr14:27000362-27002325 bp, + strand  Genetic Position: Chr14, 16.09 cM, cytoband A3-B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:47920
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (knock-out)
Mutations:    Insertion, Intragenic deletion
    Deletion of the entire coding region and replacement with a neomycin cassette. (J:47920)
Inheritance:    Recessive
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 51 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hesx1 Mutation:  0 strains or lines available
References
Original:  J:47920 Dattani MT, et al., Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse. Nat Genet. 1998 Jun;19(2):125-33
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory