Hesx1^tm1Icar
Targeted Allele Detail

Summary

• Symbol: Hesx1^tm1Icar
• Name: homeobox gene expressed in ES cells; targeted mutation 1, Iain C A F Robinson
• MGI ID: MGI:1931124
• Synonyms: Hesx1^-
• Gene: Hesx1 Location: Chr14:26716375-26724286 bp, + strand Genetic Position: Chr14, 16.09 cM, cytoband A3-B
• Alliance: Hesx1^tm1Icar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47920
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Deletion of the entire coding region and replacement with a neomycin cassette. (J:47920)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	51 assay results
In Structures Affected by this Mutation:	23 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hesx1 Mutation: 14 strains or lines available

References

• Original: J:47920 Dattani MT, et al., Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse. Nat Genet. 1998 Jun;19(2):125-33
• All: 8 reference(s)