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Vegfatm1Dco
Targeted Allele Detail
Nomenclature
Symbol: Vegfatm1Dco
Name: vascular endothelial growth factor A; targeted mutation 1, Desire Collen
MGI ID: MGI:1931046
Synonyms: VEGF-
Gene: Vegfa  Location: Chr17:46016993-46032369 bp, - strand  Genetic Position: Chr17, 22.79 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:32219
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsReplacement of exon 3 with a neomycin cassette. Low abundance of aberrant mRNA transcripts were detected by RT-PCR analysis, but these transcripts did not produce detectable expression of a functional protein product in COS cells. (J:32219)
Inheritance:    Dominant
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vegfa Mutation:  19 strains or lines available
Notes
ES cell line = D3 (129S2/SvPas), JH1 (129S7/SvEvBrd), RW4 (129X1/SvJ), or R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl+).
References
Original:  J:32219 Carmeliet P, et al., Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature. 1996 Apr 4;380(6573):435-9
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory