Vegfa^tm1Dco
Targeted Allele Detail

Summary

• Symbol: Vegfa^tm1Dco
• Name: vascular endothelial growth factor A; targeted mutation 1, Desire Collen
• MGI ID: MGI:1931046
• Synonyms: VEGF^-
• Gene: Vegfa Location: Chr17:46327919-46343295 bp, - strand Genetic Position: Chr17, 22.79 cM
• Alliance: Vegfa^tm1Dco page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:32219
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of exon 3 with a neomycin cassette. Low abundance of aberrant mRNA transcripts were detected by RT-PCR analysis, but these transcripts did not produce detectable expression of a functional protein product in COS cells. (J:32219)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vegfa Mutation: 37 strains or lines available

Notes

ES cell line = D3 (129S2/SvPas), JH1 (129S7/SvEvBrd), RW4 (129X1/SvJ), or R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl⁺).

References

• Original: J:32219 Carmeliet P, et al., Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature. 1996 Apr 4;380(6573):435-9
• All: 4 reference(s)