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Vegfatm1Gne
Targeted Allele Detail
Nomenclature
Symbol: Vegfatm1Gne
Name: vascular endothelial growth factor A; targeted mutation 1, Genentech
MGI ID: MGI:1931041
Synonyms: VEGF-
Gene: Vegfa  Location: Chr17:46016993-46032369 bp, - strand  Genetic Position: Chr17, 22.79 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:32218
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsReplacement of exon 3 and flanking intronic sequence with a neomycin cassette. Heterozygous ES cells were shown to secrete half the wild-type amount of protein by radioreceptor assay. (J:32218)
Inheritance:    Dominant
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vegfa Mutation:  19 strains or lines available
Notes
Homozygous null ES cells display a significantly impaired ability to form tumors in nude mice (J:32218).
References
Original:  J:32218 Ferrara N, et al., Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature. 1996 Apr 4;380(6573):439-42
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory