About   Help   FAQ
Vegfatm1Gne
Targeted Allele Detail
Nomenclature
Symbol: Vegfatm1Gne
Name: vascular endothelial growth factor A; targeted mutation 1, Genentech
MGI ID: MGI:1931041
Synonyms: VEGF-
Gene: Vegfa  Location: Chr17:46016993-46032369 bp, - strand  Genetic Position: Chr17, 22.79 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:32218
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsReplacement of exon 3 and flanking intronic sequence with a neomycin cassette. Heterozygous ES cells were shown to secrete half the wild-type amount of protein by radioreceptor assay. (J:32218)
Inheritance:    Dominant
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vegfa Mutation:  20 strains or lines available
Notes
Homozygous null ES cells display a significantly impaired ability to form tumors in nude mice (J:32218).
References
Original:  J:32218 Ferrara N, et al., Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature. 1996 Apr 4;380(6573):439-42
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/28/2017
MGI 6.11
The Jackson Laboratory