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Trp53tm1Brn
Targeted Allele Detail
Nomenclature
Symbol: Trp53tm1Brn
Name: transformation related protein 53; targeted mutation 1, Anton Berns
MGI ID: MGI:1931011
Synonyms: p53Co, p53F, p53F2-10, p53F2-10F, p53Fl, p53Fl, p53flox, p53L, p53lox, p53LoxP, Tp53flx, Trp53F2-10, Trp53F2-F10, Trp53Fl, Trp53loxP
Gene: Trp53  Location: Chr11:69580359-69591873 bp, + strand  Genetic Position: Chr11, 42.83 cM, cytoband B2-C
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:61961
Parent Cell Line:  IB10/E14IB10 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
    Insertion of loxP sites flanking exons 2 through 10. No effect on the normal function of the gene. (J:61961)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Trp53 Mutation:  139 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Intrahepatic CholangiocarcinomaJ:184949.

Phenotypic Similarity to Human Syndrome: Soft Tissue Sarcoma J:125101 in double Kras and Trp53 mutants.

Phenotypic Similarity to Human Syndrome: Soft Tissue Sarcoma, Undifferentiated Pleomorphic Sarcoma/Malignant Fibrous Histiocytoma J:155389, J:204376 in double Kras and Trp53 mutants.

References
Original:  J:61961 Marino S, et al., Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev. 2000 Apr 15;14(8):994-1004
All:  282 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory