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Mgmttm1Lds
Targeted Allele Detail
Nomenclature
Symbol: Mgmttm1Lds
Name: O-6-methylguanine-DNA methyltransferase; targeted mutation 1, Leona D Samson
MGI ID: MGI:1930999
Synonyms: Mgmt -
Gene: Mgmt  Location: Chr7:136894463-137128193 bp, + strand  Genetic Position: Chr7, 82.07 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:55347
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Replacement of part of exon 5, encoding the active site cysteine, with a neomycin cassette. (J:55347)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mgmt Mutation:  17 strains or lines available
References
Original:  J:55347 Glassner BJ, et al., DNA repair methyltransferase (Mgmt) knockout mice are sensitive to the lethal effects of chemotherapeutic alkylating agents. Mutagenesis. 1999 May;14(3):339-47
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory