Mlh1^tm1Mse
Targeted Allele Detail

Summary

• Symbol: Mlh1^tm1Mse
• Name: mutL homolog 1; targeted mutation 1, Mutsuo Sekiguchi
• MGI ID: MGI:1930998
• Synonyms: Mlh1^-
• Gene: Mlh1 Location: Chr9:111057296-111100854 bp, - strand Genetic Position: Chr9, 60.92 cM
• Alliance: Mlh1^tm1Mse page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47642
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Replacement of exon 16 with a neomycin cassette. (J:47642)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Mlh1^tm1Mse

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mlh1 Mutation: 42 strains or lines available

References

• Original: J:47642 Kawate H, et al., Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes. Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5116-20
• All: 3 reference(s)