Csf2^tm1Ard
Targeted Allele Detail

Summary

• Symbol: Csf2^tm1Ard
• Name: colony stimulating factor 2 (granulocyte-macrophage); targeted mutation 1, Ashley R Dunn
• MGI ID: MGI:1930997
• Synonyms: CSF-2^o, GM-, GM-CSF-
• Gene: Csf2 Location: Chr11:54138097-54140493 bp, - strand Genetic Position: Chr11, 32.13 cM
• Alliance: Csf2^tm1Ard page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:18747
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 and flanking intronic sequence was replaced by a LacZ gene, human beta globin gene 3' untranslated and poly(A) sequences and a neomycin cassette. (J:18747)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	130 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Csf2 Mutation: 33 strains or lines available

References

• Original: J:18747 Stanley E, et al., Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology. Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5592-6
• All: 56 reference(s)