About   Help   FAQ
Dnmt1tm2Enl
Targeted Allele Detail
Summary
Symbol: Dnmt1tm2Enl
Name: DNA methyltransferase 1; targeted mutation 2, En Li
MGI ID: MGI:1930971
Synonyms: Dnmt1-, Dnmt1c, Dnmtc
Gene: Dnmt1  Location: Chr9:20818501-20871084 bp, - strand  Genetic Position: Chr9, 7.66 cM
Alliance: Dnmt1tm2Enl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:36234
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsDeletion of two exons encoding the catalytic domain and replacement with either a neomycin or hygromycin cassette. (J:36234)
Inheritance:    Recessive
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 19 assay results
In Structures Affected by this Mutation: 3 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Dnmt1tm2Enl
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dnmt1 Mutation:  108 strains or lines available
References
Original:  J:36234 Lei H, et al., De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells. Development. 1996 Oct;122(10):3195-205
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory