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Ifnar1tm1Agt
Targeted Allele Detail
Nomenclature
Symbol: Ifnar1tm1Agt
Name: interferon (alpha and beta) receptor 1; targeted mutation 1, Michel Aguet
MGI ID: MGI:1930950
Synonyms: A-, A129, A 129, IFN-alpha/betaR-, IFN-alphabetaR-, IFN-alpha/betaR0, IFN-alpha/betaR/A129, IFN-alphabeta-R KO, IFN Alpha Ro/o, IFNAR-, IFNAR(0), Ifnar1-, IFN-IR-, IFN-IR KO, IFNR-, IFNRA1,-., IFNRI -, IFNR! KO, IFN type I receptor
Gene: Ifnar1  Location: Chr16:91485238-91507441 bp, + strand  Genetic Position: Chr16, 52.98 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:36115
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (knock-out)
Mutation:    Insertion
    A neomycin cassette was inserted into exon 3 at a position corresponding to amino acid 88. (J:36115, J:96036)
Inheritance:    Recessive
Phenotypes
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Disease models
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Expression
In Mice Carrying this Mutation: 4 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Ifnar1 Mutation:  9 strains or lines available
References
Original:  J:36115 Muller U, et al., Functional role of type I and type II interferons in antiviral defense. Science. 1994 Jun 24;264(5167):1918-21
All:  447 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory