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Brca2tm1Arge
Targeted Allele Detail
Nomenclature
Symbol: Brca2tm1Arge
Name: breast cancer 2; targeted mutation 1, Argiris Efstratiadis
MGI ID: MGI:1930615
Synonyms: Brca2ex11
Gene: Brca2  Location: Chr5:150522630-150569746 bp, + strand  Genetic Position: Chr5, 89.52 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:40594
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Replacement of a segment of exon 11 with a neomycin cassette. (J:40594)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Brca2 Mutation:  33 strains or lines available
References
Original:  J:40594 Ludwig T, et al., Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos. Genes Dev. 1997 May 15;11(10):1226-41
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory