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Brca1tm1Cxd
Targeted Allele Detail
Nomenclature
Symbol: Brca1tm1Cxd
Name: breast cancer 1, early onset; targeted mutation 1, Chu-Xia Deng
MGI ID: MGI:1930612
Synonyms: Brca111-, Brca1delta11, Brca1Ko, brca1Ko22
Gene: Brca1  Location: Chr11:101488764-101551955 bp, - strand  Genetic Position: Chr11, 65.18 cM, cytoband D
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:51834
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Deletion of 330 bp of intron 10 and 407 bp of exon 11 and replacement with a neomycin cassette. (J:51834)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Brca1 Mutation:  82 strains or lines available
References
Original:  J:51834 Shen SX, et al., A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability. Oncogene. 1998 Dec 17;17(24):3115-24
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory