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Agrntm1Jrs
Targeted Allele Detail
Nomenclature
Symbol: Agrntm1Jrs
Name: agrin; targeted mutation 1, Joshua R Sanes
MGI ID: MGI:1929777
Synonyms: agrin-, agrnneo, z-agrin-
Gene: Agrn  Location: Chr4:156165290-156197488 bp, - strand  Genetic Position: Chr4, 88.55 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:33098
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Hypomorph, Modified isoform(s))
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsReplacement of exons 32 and 33, encoding the "z" alternative splice exons, with a neomycin cassette. Note this is a hypomorphic allele for all isoforms of agrin. (J:33098)
Inheritance:    Recessive
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 36 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Agrn Mutation:  43 strains or lines available
References
Original:  J:33098 Gautam M, et al., Defective neuromuscular synaptogenesis in agrin-deficient mutant mice. Cell. 1996 May 17;85(4):525-35
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory