Csk^tm1Sia
Targeted Allele Detail

Summary

• Symbol: Csk^tm1Sia
• Name: c-src tyrosine kinase; targeted mutation 1, Shinichi Aizawa
• MGI ID: MGI:1929683
• Synonyms: Csk-, Csk^cz
• Gene: Csk Location: Chr9:57533929-57560758 bp, - strand Genetic Position: Chr9, 31.18 cM
• Alliance: Csk^tm1Sia page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:12623
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ/neomycin gene fusion was inserted into an exon encoding the kinase domain. This allele expresses a fusion protein of the N-terminal region to beta-galactosidase. (J:12623)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Csk Mutation: 27 strains or lines available

References

• Original: J:12623 Nada S, et al., Constitutive activation of Src family kinases in mouse embryos that lack Csk. Cell. 1993 Jun 18;73(6):1125-35
• All: 2 reference(s)