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Erbb3tm2Cbm
Targeted Allele Detail
Nomenclature
Symbol: Erbb3tm2Cbm
Name: v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian); targeted mutation 2, Carmen Birchmeier
MGI ID: MGI:1929598
Synonyms: erbB3-, Erbb3KO2
Gene: Erbb3  Location: Chr10:128567523-128589652 bp, - strand  Genetic Position: Chr10, 77.1 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:43515
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin gene was fused to an exon encoding extracellular sequences of the protein, introducing termination codons in all three reading frames. No protein is produced from this allele. (J:43515)
Inheritance:    Recessive
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Erbb3 Mutation:  9 strains or lines available
References
Original:  J:43515 Riethmacher D, et al., Severe neuropathies in mice with targeted mutations in the ErbB3 receptor. Nature. 1997 Oct 16;389(6652):725-30
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory