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Erbb3tm1Cbm
Targeted Allele Detail
Nomenclature
Symbol: Erbb3tm1Cbm
Name: erb-b2 receptor tyrosine kinase 3; targeted mutation 1, Carmen Birchmeier
MGI ID: MGI:1929072
Synonyms: erbB3delta, Erbb3KO1
Gene: Erbb3  Location: Chr10:128567523-128589635 bp, - strand  Genetic Position: Chr10, 77.1 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:43515
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons encoding a large part of the extracellular domain of the protein were deleted and replaced by a neomycin cassette. A truncated protein is produced from this allele. (J:43515)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Erbb3 Mutation:  8 strains or lines available
References
Original:  J:43515 Riethmacher D, et al., Severe neuropathies in mice with targeted mutations in the ErbB3 receptor. Nature. 1997 Oct 16;389(6652):725-30
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory