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Erbb2tm1Cbm
Targeted Allele Detail
Nomenclature
Symbol: Erbb2tm1Cbm
Name: v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian); targeted mutation 1, Carmen Birchmeier
MGI ID: MGI:1929071
Synonyms: erbB2-
Gene: Erbb2  Location: Chr11:98412470-98437716 bp, + strand  Genetic Position: Chr11, 61.75 cM, cytoband D
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:48515
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsFusion of lacZ sequences to an exon encoding the cytoplasmic juxtamembrane domain. This allele expresses a fusion protein of ErbB2 and beta-galactosidase that lacks the kinase domain of ErbB2. (J:48515)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Erbb2 Mutation:  3 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Dilated Cardiomyopathy in mice with conditional deletion in cardiomyocytes (J:77347)

References
Original:  J:48515 Britsch S, et al., The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system. Genes Dev. 1998 Jun 15;12(12):1825-36
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory