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Scarb1tm1Dhu
Targeted Allele Detail
Nomenclature
Symbol: Scarb1tm1Dhu
Name: scavenger receptor class B, member 1; targeted mutation 1, Dennis Huszar
MGI ID: MGI:1928989
Synonyms: SR-BI att
Gene: Scarb1  Location: Chr5:125277087-125341094 bp, - strand  Genetic Position: Chr5, 64.11 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:47439
Parent Cell Line:  RF8 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Hypomorph)
Mutation:    Insertion
 
Mutation detailsDisruption of the putative promoter region by insertion of a vector. This is a hypomorphic allele; expression levels are reduced to varying degrees in different tissues. (J:47439)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scarb1 Mutation:  26 strains or lines available
References
Original:  J:47439 Varban ML, et al., Targeted mutation reveals a central role for SR-BI in hepatic selective uptake of high density lipoprotein cholesterol [see comments]. Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4619-24
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory