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Targeted Allele Detail
Symbol: Nrg1tm1Lwr
Name: neuregulin 1; targeted mutation 1, Lorna W Role
MGI ID: MGI:1928831
Synonyms: CRD-NRG-1-, Nrg1Lwrtm1, Nrg1tm1.1Lwr, Type III Nrg1-
Gene: Nrg1  Location: Chr8:31814551-32884029 bp, - strand  Genetic Position: Chr8, 18.75 cM
Germline Transmission:  Earliest citation of germline transmission: J:60159
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsDisruption of the "CRD-domain" alternative splice N-terminus by insertion of a nonsense mutation and an Xba1 site in the exon encoding the CRD domain. A lox-P flanked neo gene is also inserted into the intron following the CRD-encoding exon. (J:60159)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nrg1 Mutation:  20 strains or lines available
Original:  J:60159 Wolpowitz D, et al., Cysteine-rich domain isoforms of the neuregulin-1 gene are required for maintenance of peripheral synapses. Neuron. 2000 Jan;25(1):79-91
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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