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Targeted Allele Detail
Symbol: Chek1tm1Mkt
Name: checkpoint kinase 1; targeted mutation 1, Makoto Nakanishi
MGI ID: MGI:1928818
Synonyms: Chk1-
Gene: Chek1  Location: Chr9:36708482-36727065 bp, - strand  Genetic Position: Chr9, 20.67 cM, cytoband A5.3
Germline Transmission:  Earliest citation of germline transmission: J:62918
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsReplacement of a 2.5kb region containing exons 1 and 2 with a neomycin cassette. The translation initiation site and the sequences encoding the ATP-binding region of the kinase are deleted. (J:62918)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chek1 Mutation:  26 strains or lines available
Original:  J:62918 Takai H, et al., Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice. Genes Dev. 2000 Jun 15;14(12):1439-47
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory