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Gene trapped Allele Detail
Symbol: CrebbpGt(U-San)112Imeg
Name: CREB binding protein; gene trap 112, Institute of Molecular Embryology and Genetics
MGI ID: MGI:1928775
Synonyms: CBP+/-
Gene: Crebbp  Location: Chr16:4081328-4213997 bp, - strand  Genetic Position: Chr16, 2.4 cM
Germline Transmission:  Earliest citation of germline transmission: J:53370
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Gene trapped
Mutation:    Insertion of gene trap vector
Mutation detailsInsertion of the gene trap vector pU-San into an intron of the Crebbp gene located between the exons containing nucleotides 3064-3253 and 3254-3373. Mice carrying this allele express a 121 kd truncated form of the Crebbp protein. (J:53370)
View phenotypes and curated references for all genotypes (concatenated display).
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Crebbp Mutation:  62 strains or lines available
Original:  J:53370 Oike Y, et al., Truncated CBP protein leads to classical Rubinstein-Taybi syndrome phenotypes in mice: implications for a dominant-negative mechanism. Hum Mol Genet. 1999 Mar;8(3):387-96
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory