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Nrg1tm1Leth
Targeted Allele Detail
Nomenclature
Symbol: Nrg1tm1Leth
Name: neuregulin 1; targeted mutation 1, Lars E Theill
MGI ID: MGI:1928491
Synonyms: neuregulinIg, Nrg -
Gene: Nrg1  Location: Chr8:31814551-32884029 bp, - strand  Genetic Position: Chr8, 18.75 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:33038
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Part of exon 3, encoding the Ig domain, was replaced with a PGK-neomycin cassette (J:33038)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 5 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nrg1 Mutation:  17 strains or lines available
References
Original:  J:33038 Kramer R, et al., Neuregulins with an Ig-like domain are essential for mouse myocardial and neuronal development. Proc Natl Acad Sci U S A. 1996 May 14;93(10):4833-8
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory