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Grin2btm1Rsp
Targeted Allele Detail
Nomenclature
Symbol: Grin2btm1Rsp
Name: glutamate receptor, ionotropic, NMDA2B (epsilon 2); targeted mutation 1, Rolf Sprengel
MGI ID: MGI:1928293
Synonyms: NR2BdeltaC
Gene: Grin2b  Location: Chr6:135713233-136173511 bp, - strand  Genetic Position: Chr6, 66.38 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:45446
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExpression of a receptor lacking the intracellular C-terminal domain by insertion of a PGK-neomycin cassette 3' to the M4 transmembrane coding region, with translation stop codons in three frames. (J:45446)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grin2b Mutation:  36 strains or lines available
References
Original:  J:45446 Sprengel R, et al., Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo. Cell. 1998 Jan 23;92(2):279-89
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/13/2017
MGI 6.10
The Jackson Laboratory