Grin1^tm1Bhk
Targeted Allele Detail

Summary

• Symbol: Grin1^tm1Bhk
• Name: glutamate receptor, ionotropic, NMDA1 (zeta 1); targeted mutation 1, Beverly H Koller
• MGI ID: MGI:1928280
• Synonyms: GluN1^Rneo, NR1^-, NR1KD, Nr1^neo, Nr1^neo-
• Gene: Grin1 Location: Chr2:25181193-25209199 bp, - strand Genetic Position: Chr2, 17.14 cM
• Alliance: Grin1^tm1Bhk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57125
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Insertion
• Mutation details: Hypomorphic allele. Insertion of a neomycin cassette into intron 20 of the gene reduces expression to ~5-10% of normal levels. (J:57125)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Grin1 Mutation: 64 strains or lines available

References

• Original: J:57125 Mohn AR, et al., Mice with reduced NMDA receptor expression display behaviors related to schizophrenia. Cell. 1999 Aug 20;98(4):427-36
• All: 25 reference(s)