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Spi1tm1Ram
Targeted Allele Detail
Nomenclature
Symbol: Spi1tm1Ram
Name: spleen focus forming virus (SFFV) proviral integration oncogene; targeted mutation 1, Richard A Maki
MGI ID: MGI:1927876
Synonyms: PU.1 (-)
Gene: Spi1  Location: Chr2:91082390-91115756 bp, + strand  Genetic Position: Chr2, 50.44 cM, cytoband E3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:36473
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
    Insertion of a neomycin gene into exon 5, which encodes the DNA binding domain. (J:36473)
Inheritance:    Recessive
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 31 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Spi1 Mutation:  7 strains or lines available
References
Original:  J:36473 McKercher SR, et al., Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. EMBO J. 1996 Oct 15;15(20):5647-58
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory