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Nkx3-1tm1Mms
Targeted Allele Detail
Nomenclature
Symbol: Nkx3-1tm1Mms
Name: NK3 homeobox 1; targeted mutation 1, Michael M Shen
MGI ID: MGI:1926960
Synonyms: Nkx3.1-
Gene: Nkx3-1  Location: Chr14:69190692-69194658 bp, + strand  Genetic Position: Chr14, 36.02 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:54465
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsReplacement of sequences encoding the homeodomain and carboxy-terminus of the gene with a PGK-neomycin cassette. (J:54465)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Nkx3-1 Mutation:  20 strains or lines available
References
Original:  J:54465 Bhatia-Gaur R, et al., Roles for Nkx3.1 in prostate development and cancer. Genes Dev. 1999 Apr 15;13(8):966-77
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory