Tg(rv-CYCLIN)29Dlh
Transgene Detail

Summary

• Symbol: Tg(rv-CYCLIN)29Dlh
• Name: transgene insertion 29, Donald L Holzschu
• MGI ID: MGI:1926798
• Synonyms: rv-cyclin
• Transgene: Tg(rv-CYCLIN)29Dlh Location: unknown
• Alliance: Tg(rv-CYCLIN)29Dlh page

Runting and alopecia in Tg(rv-CYCLIN)29Dlh/0 mice

Show the 2 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: Overexpression of walleye epidermal hyperplasia virus type 1 (WDSV1) rv-cyclin in squamous epithelial cells, driven by the bovine keratin-5 (KRT5) promoter. (J:62478)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Transgenic mouse line number 29 is representative of several other lines with an similar phenotype. These include lines 33, 105, 120, 150 and 180. These lines have some variability in the severity of the phenotypes listed above.

References

• Original: J:62478 Lairmore MD, et al., Squamous epithelial proliferation induced by walleye dermal sarcoma retrovirus cyclin in transgenic mice. Proc Natl Acad Sci U S A. 2000 May 23;97(11):6114-9
• All: 1 reference(s)