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Itgb6tm1Des
Targeted Allele Detail
Nomenclature
Symbol: Itgb6tm1Des
Name: integrin beta 6; targeted mutation 1, Dean Sheppard
MGI ID: MGI:1926484
Synonyms: beta6-, Itgb6-
Gene: Itgb6  Location: Chr2:60598292-60722643 bp, - strand  Genetic Position: Chr2, 34.81 cM, cytoband C3
Juvenile baldness in Itgb6tm1Des/Itgb6tm1Des mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:33139
Parent Cell Line:  RF8 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
    Insertion of a neomycin gene into a coding exon of the Itgb6 gene. (J:33139)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itgb6 Mutation:  13 strains or lines available
References
Original:  J:33139 Huang XZ, et al., Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin. J Cell Biol. 1996 May;133(4):921-8
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory