Gfra2^tm1Msa
Targeted Allele Detail

Summary

• Symbol: Gfra2^tm1Msa
• Name: glial cell line derived neurotrophic factor family receptor alpha 2; targeted mutation 1, Matti S Airaksinen
• MGI ID: MGI:1926440
• Synonyms: Gfra2-, Gfralpha-2-, Gfralpha2-, GFRalpha2-KO
• Gene: Gfra2 Location: Chr14:71127560-71217278 bp, + strand Genetic Position: Chr14, 36.79 cM, cytoband D3-E1
• Alliance: Gfra2^tm1Msa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53284
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Replacement of part of first coding exon of the gene with PGK-neomycin cassette. (J:53284)

Expression

In Mice Carrying this Mutation:	62 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gfra2 Mutation: 23 strains or lines available

References

• Original: J:53284 Rossi J, et al., Retarded growth and deficits in the enteric and parasympathetic nervous system in mice lacking GFR alpha2, a functional neurturin receptor. Neuron. 1999 Feb;22(2):243-52
• All: 25 reference(s)