Gfra1^tm1Jmi
Targeted Allele Detail

Summary

• Symbol: Gfra1^tm1Jmi
• Name: glial cell line derived neurotrophic factor family receptor alpha 1; targeted mutation 1, Jeffrey Milbrandt
• MGI ID: MGI:1926439
• Synonyms: Gfra1-, GFRalpha-1-, GFRalpha1-
• Gene: Gfra1 Location: Chr19:58224036-58444341 bp, - strand Genetic Position: Chr19, 54.18 cM, cytoband D2-D3
• Alliance: Gfra1^tm1Jmi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49471
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of the first and second exons of Gfra1 with pGK-neomycin cassette. Absence of expression was confirmed by Northern blots on brain poly(A)+RNA. (J:49471)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gfra1 Mutation: 31 strains or lines available

References

• Original: J:49471 Enomoto H, et al., GFR alpha1-deficient mice have deficits in the enteric nervous system and kidneys. Neuron. 1998 Aug;21(2):317-24
• All: 16 reference(s)