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Targeted Allele Detail
Symbol: Tcf7tm2Cle
Name: transcription factor 7, T cell specific; targeted mutation 2, Hans Clevers
MGI ID: MGI:1926299
Synonyms: TcfdeltaV
Gene: Tcf7  Location: Chr11:52252371-52283014 bp, - strand  Genetic Position: Chr11, 31.86 cM
Germline Transmission:  Earliest citation of germline transmission: J:23255
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Hypomorph)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 350-bp fragment encoding part of intron IV and exon V was replaced with a neomycin cassette. A novel mRNA was detected in homozgyote thymocytes at 15% of the wild-type mRNA level. This mutant mRNA contains a splice variant of exon 4 to exon 6. This allele is considered a hypomorph. (J:23255)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tcf7 Mutation:  8 strains or lines available
Original:  J:23255 Verbeek S, et al., An HMG-box-containing T-cell factor required for thymocyte differentiation. Nature. 1995 Mar 2;374(6517):70-4
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.13
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