Tcf7^tm1Cle
Targeted Allele Detail

Summary

• Symbol: Tcf7^tm1Cle
• Name: transcription factor 7, T cell specific; targeted mutation 1, Hans Clevers
• MGI ID: MGI:1926298
• Synonyms: Tcf-1-, Tcf1^-, Tcf1^Hom, Tcf7^-, Tcf^deltaVII
• Gene: Tcf7 Location: Chr11:52143198-52174158 bp, - strand Genetic Position: Chr11, 31.86 cM
• Alliance: Tcf7^tm1Cle page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:23255
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A 67-bp fragment encoding exon VII was replaced with a neomycin cassette. (J:23255)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tcf7^tm1Cle

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcf7 Mutation: 24 strains or lines available

References

• Original: J:23255 Verbeek S, et al., An HMG-box-containing T-cell factor required for thymocyte differentiation. Nature. 1995 Mar 2;374(6517):70-4
• All: 63 reference(s)