About   Help   FAQ
Chrnb2tm1Jpc
Targeted Allele Detail
Nomenclature
Symbol: Chrnb2tm1Jpc
Name: cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal); targeted mutation 1, Jean-Pierre Changeux
MGI ID: MGI:1926253
Synonyms: beta2-, beta2-KO
Gene: Chrnb2  Location: Chr3:89746195-89764632 bp, - strand  Genetic Position: Chr3, 39.19 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:23256
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe start codon and the rest of exon 1 was replaced by a lacZ reporter gene and a neomycin resistance gene. (J:23256)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chrnb2 Mutation:  16 strains or lines available
References
Original:  J:23256 Picciotto MR, et al., Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain. Nature. 1995 Mar 2;374(6517):65-7
All:  71 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/12/2018
MGI 6.12
The Jackson Laboratory