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Gene trapped Allele Detail
Symbol: Gt(ROSA)26Sor
Name: gene trap ROSA 26, Philippe Soriano
MGI ID: MGI:1890203
Synonyms: gtrosa26, R26R3, R26tg, ROSA26, Rosa26lacZ, ROSA26-lacZ, TgR(ROSA26)26Sor
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
Mutant Cell Line:  FHCRC-GT-ROSA26
Germline Transmission:  Earliest citation of germline transmission: J:79478
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Allele Type:    Gene trapped (Not Applicable)
Mutation:    Insertion of gene trap vector     Vector: ROSABetageo
Mutation detailsRandom insertion of retroviral gene trap vector ROSA, Reverse Orientation with Splice Acceptor, which contains the beta-galactosidase gene and accompanying splice acceptor and neo sequences. The construct was inserted in reverse orientation in the retroviral vector pGen-. The transgene is controlled by an unknown endogenous promoter. lacZ is expressed in all tissues of the developing embryo and in most tissues of the adult transgenic mouse. (J:39814, J:79478)
Inheritance:    Not Specified
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 4 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 16 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  536 strains or lines available
ES cell line = AB1 or AB2.1. No overt phenotypes in heterozygous or homozygous animals. The trapped gene appears to be ubiquitously expressed during embryonic development and in all hematopoietic cells.
Original:  J:79478 Friedrich G, et al., Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev. 1991 Sep;5(9):1513-23
All:  99 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
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