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Vegfatm1.1Nagy
Targeted Allele Detail
Nomenclature
Symbol: Vegfatm1.1Nagy
Name: vascular endothelial growth factor A; targeted mutation 1.1, Andras Nagy
MGI ID: MGI:1889787
Synonyms: VEGF-Ahyper, Vegfhi, Vegf-IRES-lacZ, VEGFLacZ, VEGFlacZ-KI, VEGF-LacZ-KI-delta-neo
Gene: Vegfa  Location: Chr17:46016993-46032369 bp, - strand  Genetic Position: Chr17, 22.79 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:56939
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsThis allele is a derivative of Vegftm1Nagy where the PGK-neomycin resistance cassette has been deleted via a Cre/loxP recombination event. The allele expresses a bicistronic message encoding VEGF and LacZ proteins. (J:56939)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 119 assay results
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Vegfa Mutation:  24 strains or lines available
Notes
The LacZ staining from this allele is indistinguishable from Vegftm1Nagy.
References
Original:  J:56939 Miquerol L, et al., Multiple developmental roles of VEGF suggested by a LacZ-tagged allele. Dev Biol. 1999 Aug 15;212(2):307-22
All:  31 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory