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LeprTg(Mth11)1Aig
Transgenic Allele Detail
Nomenclature
Symbol: LeprTg(Mth11)1Aig
Name: leptin receptor; transgene insertion 1, Bernhard Aigner
MGI ID: MGI:1888983
Gene: Lepr  Location: Chr4:101717404-101815352 bp, + strand  Genetic Position: Chr4, 46.96 cM
Transgene
origin
Strain of Origin:  Him:OF1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Intragenic deletion
 
Mutation detailsThe mutation was caused by insertion of a transgene. The construct contained 2.3 kb of the rabbit smooth muscle myosin heavy chain promoter region. The deletion extends from intron 17 into the 3' region of the gene. (J:61119)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lepr Mutation:  76 strains or lines available
Notes

Authors report variations in the obesity and diabetes phenotypes with the outbred mice (Him:Of1).

References
Original:  J:61119 Reichart U, et al., Contrasting obesity phenotypes uncovered by partial leptin receptor gene deletion in transgenic mice. Biochem Biophys Res Commun. 2000 Mar 16;269(2):502-7
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory