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Ackr1tm1Scp
Targeted Allele Detail
Nomenclature
Symbol: Ackr1tm1Scp
Name: atypical chemokine receptor 1 (Duffy blood group); targeted mutation 1, Stephen C Peiper
MGI ID: MGI:1888977
Synonyms: DARC-
Gene: Ackr1  Location: Chr1:173159453-173161070 bp, - strand  Genetic Position: Chr1, 80.33 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:64222
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsGenomic sequences corresponding to part of intron 1 and 90 bp of intron 2 were replaced by a neomycin resistance cassette. RT-PCR analysis demonstrated that a nonfunctional message is produced from this allele in total RNA derived from spleen. Binding assays demonstrated a lack of functional protein in homozygous mice. (J:64222)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ackr1 Mutation:  12 strains or lines available
References
Original:  J:64222 Dawson TC, et al., Exaggerated response to endotoxin in mice lacking the duffy antigen/receptor for chemokines (DARC). Blood. 2000 Sep 1;96(5):1681-4
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory