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Cdkn1atm1Led
Targeted Allele Detail
Nomenclature
Symbol: Cdkn1atm1Led
Name: cyclin-dependent kinase inhibitor 1A (P21); targeted mutation 1, Philip Leder
MGI ID: MGI:1888950
Synonyms: p21-, p21Cip1, p21Cip1/Waf1 -, p21CIP1/WAF1
Gene: Cdkn1a  Location: Chr17:29090979-29100722 bp, + strand  Genetic Position: Chr17, 15.12 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:28420
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    A PGK-neomycin resistance cassette replaced a 3kb sequence containing exon 2. (J:28420)
Inheritance:    Recessive
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 33 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdkn1a Mutation:  44 strains or lines available
References
Original:  J:28420 Deng C, et al., Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell. 1995 Aug 25;82(4):675-84
All:  90 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory