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Targeted Allele Detail
Symbol: Fli1tm2Adh
Name: Friend leukemia integration 1; targeted mutation 2, Adam Hart
MGI ID: MGI:1888943
Synonyms: Fli-1Z/Z, PNTFliZ, PNTFliZ-(Fli-1Z/Z)
Gene: Fli1  Location: Chr9:32422204-32542861 bp, - strand  Genetic Position: Chr9, 17.74 cM
Germline Transmission:  Earliest citation of germline transmission: J:64178
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA lacZ gene was fused in frame into exon 7 followed by a neomycin resistance cassette. Western blot analysis on extracts derived from E9.5 homozygous embryos confirmed that no detectable protein is expressed from this allele. (J:64178)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fli1 Mutation:  15 strains or lines available
Original:  J:64178 Hart A, et al., Fli-1 is required for murine vascular and megakaryocytic development and is hemizygously deleted in patients with thrombocytopenia. Immunity. 2000 Aug;13(2):167-77
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory