Gsk3btm1Jrw
Targeted Allele Detail
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Symbol: |
Gsk3btm1Jrw |
Name: |
glycogen synthase kinase 3 beta; targeted mutation 1, James R Woodgett |
MGI ID: |
MGI:1888887 |
Synonyms: |
gsk3b-, GSK-3beta- |
Gene: |
Gsk3b Location: Chr16:37909363-38066446 bp, + strand Genetic Position: Chr16, 26.54 cM, cytoband B4
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Alliance: |
Gsk3btm1Jrw page
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Increased bone mass in Gsk3btm1Jrw/Gsk3b+ mice
Show the 2 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:63274
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neomycin resistance cassette replaced an exon encoding the ATP-binding loop. Southern and Western blots of embryonic fibroblasts (E12.5) showed no detectable DNA and protein of the targeted gene, respectively.
(J:63274)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gsk3b Mutation: |
111 strains or lines available
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Original: |
J:63274 Hoeflich KP, et al., Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation [see comments]. Nature. 2000 Jul 6;406(6791):86-90 |
All: |
34 reference(s) |
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