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Targeted Allele Detail
Symbol: Cdkn1btm1Kin
Name: cyclin-dependent kinase inhibitor 1B; targeted mutation 1, Kei-ichi Nakayama
MGI ID: MGI:1888790
Synonyms: p27-, p27Kip1, p27Kip1-
Gene: Cdkn1b  Location: Chr6:134897364-134902476 bp, + strand  Genetic Position: Chr6, 65.77 cM
Germline Transmission:  Earliest citation of germline transmission: J:33402
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neomycin resistance cassette in reverse orientation replaced a 2.5kb sequence containing exons 1 and 2. This deletes the entire coding portion of the gene. Immunoblots of whole tissue lysates of the thymus demnonstrate the absence of protein product. (J:33402)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 44 assay results
In Structures Affected by this Mutation: 19 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdkn1b Mutation:  20 strains or lines available
Original:  J:33402 Nakayama K, et al., Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell. 1996 May 31;85(5):707-20
All:  31 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.21
The Jackson Laboratory