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Nf2tm1Gth
Targeted Allele Detail
Nomenclature
Symbol: Nf2tm1Gth
Name: neurofibromatosis 2; targeted mutation 1, Gilles Thomas
MGI ID: MGI:1888776
Synonyms: Nf2KO3
Gene: Nf2  Location: Chr11:4765845-4849536 bp, - strand  Genetic Position: Chr11, 3.0 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:63264
Parent Cell Line:  IB10/E14IB10 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
    A IRES-lacZ-PGK-hygromycin resistance cassette was inserted into exon 3 of the gene. (J:63264)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nf2 Mutation:  47 strains or lines available
References
Original:  J:63264 Giovannini M, et al., Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2. Genes Dev. 2000 Jul 1;14(13):1617-30
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory