Chrm3^tm1Mmt
Targeted Allele Detail

Summary

• Symbol: Chrm3^tm1Mmt
• Name: cholinergic receptor, muscarinic 3, cardiac; targeted mutation 1, Makoto M Taketo
• MGI ID: MGI:1888740
• Synonyms: Chrm3-, M3 KO, M3R KO
• Gene: Chrm3 Location: Chr13:9925522-10410883 bp, - strand Genetic Position: Chr13, 3.72 cM
• Alliance: Chrm3^tm1Mmt page

Pupil appearance of Chrm3^tm1Mmt/⁺ and Chrm3^tm1Mmt/Chrm3^tm1Mmt mice.

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64069
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.5kb fragment including the translation initiation codon was replaced with a neomycin resistance cassette. (J:64069)
• Inheritance: Semidominant

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chrm3 Mutation: 50 strains or lines available

References

• Original: J:64069 Matsui M, et al., Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M3 subtype. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9579-84
• All: 18 reference(s)