About   Help   FAQ
Chrm3tm1Mmt
Targeted Allele Detail
Nomenclature
Symbol: Chrm3tm1Mmt
Name: cholinergic receptor, muscarinic 3, cardiac; targeted mutation 1, Makoto M Taketo
MGI ID: MGI:1888740
Synonyms: Chrm3-, M3 KO
Gene: Chrm3  Location: Chr13:9875486-10360844 bp, - strand  Genetic Position: Chr13, 3.72 cM
Pupil appearance of Chrm3tm1Mmt/+ and Chrm3tm1Mmt/Chrm3tm1Mmt mice.

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:64069
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 1.5kb fragment including the translation initiation codon was replaced with a neomycin resistance cassette. (J:64069)
Inheritance:    Semidominant
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chrm3 Mutation:  31 strains or lines available
References
Original:  J:64069 Matsui M, et al., Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M3 subtype. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9579-84
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/11/2018
MGI 6.12
The Jackson Laboratory