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Targeted Allele Detail
Symbol: Ndst1tm1Ekf
Name: N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1; targeted mutation 1, Erik Forsberg
MGI ID: MGI:1888706
Synonyms: NDST-1-
Gene: Ndst1  Location: Chr18:60685978-60713389 bp, - strand  Genetic Position: Chr18, 34.38 cM, cytoband D2
Newborn Ndst1tm1Ekf/Ndst1tm1Ekf mice display lung atelectasia

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:63996
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe functional mutant was generated by replacing the 3' portion of exon 1, which included the first 171 amino acids comprising both the cytoplasmic and trans-Golgi membrance domains, with a PGK-neo cassette. (J:63996)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ndst1 Mutation:  3 strains or lines available
Original:  J:63996 Ringvall M, et al., Defective heparan sulfate biosynthesis and neonatal lethality in mice lacking N-deacetylase/N-sulfotransferase-1. J Biol Chem. 2000 Aug 25;275(34):25926-30
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.21
The Jackson Laboratory