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Tgfb2tm1Doe
Targeted Allele Detail
Nomenclature
Symbol: Tgfb2tm1Doe
Name: transforming growth factor, beta 2; targeted mutation 1, Thomas Doetschman
MGI ID: MGI:1888389
Synonyms: TGBbeta2-, Tgfb2-, TGF-beta2-
Gene: Tgfb2  Location: Chr1:186623186-186705992 bp, - strand  Genetic Position: Chr1, 89.95 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:41682
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 141 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tgfb2 Mutation:  5 strains or lines available
Notes
Homozygotes exhibit a "Peters'-like" anomaly instead of an Axenfeld-Reiger's and Peter's anomaly (J:73681).

References
Original:  J:41682 Sanford LP, et al., TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes. Development. 1997 Jul;124(13):2659-70
All:  41 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory